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Venkatasubramanian, Padma
- Amla (Phyllanthus emblica L.) Enhances Iron Dialysability and Uptake in In vitro Models
Abstract Views :318 |
PDF Views:104
Authors
Padma Venkatasubramanian
1,
Indu Bala Koul
1,
Reeja Kochuthekil Varghese
1,
Srividya Koyyala
1,
Arun Shivakumar
1
Affiliations
1 Institute of Ayurveda and Integrative Medicine, No. 74/2, Jarakbande Kaval, Post: Attur, Via Yelahanka, Bangalore 560 106, IN
1 Institute of Ayurveda and Integrative Medicine, No. 74/2, Jarakbande Kaval, Post: Attur, Via Yelahanka, Bangalore 560 106, IN
Source
Current Science, Vol 107, No 11 (2014), Pagination: 1859-1866Abstract
Phyllanthus emblica L. (Indian gooseberry or amla) is a well-known dietary supplement (Rasayana) in Ayurveda used in the management of iron deficiency anaemia (Pandu). Amla is said to act by regulating the 'metabolic fire' (agni), which is important for proper digestion and absorption of nutrients. In the present study standard cell-free and cell-based models that are employed in biomedical sciences to study digestion and bioavailability of nutrients were used to examine the influence of amla fruit juice on iron dialysability and uptake. Amla juice contained 0.35% ascorbic acid (AA), 0.33% tannins (gallic acid equivalent), 0.13% gallic acid, 0.58% total organic acid and 0.002% iron on a w/w basis. Amla juice exhibited a dose response to iron dialysability with an optimum at 1 : 0.25 molar ratio of Fe : amla juice (AA equivalent) in the cell-free digestion model and 1 : 0.5 in both Caco-2 and HepG2 cell lines. Amla juice increased the dialysable iron three times more than the FeSO4 alone control in the cell-free digestion model. Iron uptake in Caco-2 and HepG2 cell lines increased 17.18 and 18.71 times more than the control respectively, in the presence of amla juice. AA, a known Fe bioavailability enhancer, at the same molar ratios showed an enhancement only by 1.45 times in the cell-free model and 13.01 and 12.48 times in the Caco-2 and HepG2 models respectively. As a dietary supplement that enhances iron dialysability and uptake, amla fruits can be explored further as a low-cost intervention in the management of iron deficiency anaemia.Keywords
Anaemia, Amla, Iron Bioavailability, In vitro Digestion Model.Full Text
- Comparative Analysis of Major Alkaloids in Piper Species Traded as 'Pippali' in South Indian Markets:Absence of the Chief Known Constituent - Piperine in Selected Samples
Abstract Views :241 |
PDF Views:68
Authors
Affiliations
1 School of Life Sciences, Institute of Transdisciplinary Health Sciences and Technology, Foundation for Revitalisation of Local Health Traditions (FRLHT), 74/2, Jarakabande Kaval Attur PO, Yelahanka, Bengaluru 560 064, IN
2 Department of Forestry, North Eastern Regional Institute of Science and Technology (NERIST), Nirjuli 791 109, IN
1 School of Life Sciences, Institute of Transdisciplinary Health Sciences and Technology, Foundation for Revitalisation of Local Health Traditions (FRLHT), 74/2, Jarakabande Kaval Attur PO, Yelahanka, Bengaluru 560 064, IN
2 Department of Forestry, North Eastern Regional Institute of Science and Technology (NERIST), Nirjuli 791 109, IN
Source
Current Science, Vol 111, No 9 (2016), Pagination: 1507-1510Abstract
The major alkaloids in piper species traded in South Indian markets as the Ayurvedic drug, Pippali, have been studied using a rapid HPLC-based method. Piper longum is the accepted botanical source of Pippali. Bengaluru and Chennai markets contained mixtures of closely related species, Piper peepuloides and Piper sylvaticum. Chemical analysis showed that these sam-ples do not contain the alkaloid piperine present in Piper longum fruits. Market samples from Trissur were identified as Piper longum and piperine was detected as one of the major alkaloids. All the samples contained pellitorine, another alkaloid reported in most peppers of the genus Piper. The two types of Pippali can therefore be easily differentiated on the basis of their HPLC profiles.Keywords
Alkaloids, Ayurvedic Drug, HPLC, Pippali, Piper longum, Piperine.Full Text
References
- Kumar, N., Dwivedi, K. N. and Ram, B., Adulteration and substi-tution of medicinal plant: a burning problem in herbal industry. Int. J. Pharm. Biol. Sci. Arch., 2014, 5(3), 13–18; Vasudevan, N. K., Yoganarasimhan, K. R., Kehava Murthy and Shantha, T. R., Studies on some south Indian market samples of Ayurvedic drugs II. Anc. Sci. Life, 1983, 3(2), 60–66.
- Cordell, G., Phytochemistry and traditional medicine – the revolu-tion continues. Phytochem. Lett., 2014, 10, xxviii–xl; Rasheed, N. M., Nagaiah, K., Goud, P. R. and Sharma, V. U. M., Chemical marker compounds and their essential role in quality control of herbal medicines. Ann. Phytomed., 2012, 1(1), 1–8.
- Anon., Ayurvedic Formulary of India, Department of Indian Sys-tems of Medicine, Ministry of Health and Family Welfare Government of India, Part 1, 2000, 1st edn, p. 322; FRLHT’s Clinically Important Plants of Ayurveda, CD, Version 1.0 Founda-tion for Revitalisation of Local Health Traditions, Bangalore, 2002.
- Sharma, P. V., (editor-translator), Caraka Samhita, Chowkhambha Orientalia, New Delhi, 2005, vol. 2, pp. 23–24; Murthy, K. R. S. (translator). Astanga Hridayam, Krishna Das Academy, Varanasi, vol. 3, p. 397.
- Pandey, G. S. (ed.), Bhavaprakasa Nighantu, Chowkhambha Bha-rati Academy, Varanasi, 2004, p. 15.
- Tripathi, I. (ed.), Rajanighantu, Chowkhamba Krishna Das Aca-demy, Varanasi, 2006, p. 134; Sharma, P. V., Dhanvantari Nighantu, Chowkhamba Orientalia, Varanasi, 2005, p. 83.
- Agarwal, A. and Murali, B., Quality Assessment of Selected Indian Medicinal Plants, National Medicinal Plant Board, New Delhi and Natural Remedies Pvt Ltd, Bengaluru, 2010, vol. 1, pp. 181–207; Indian Pharmacopeia, Indian Pharmacopeia Commission, Gha-ziabad, 2007, pp. 2057–2058; Quality Standards of Indian Medic-inal Plants, ICMR, New Delhi, 2003, vol. 1, p. 168.
- Zaveri, M., Khandar, A., Patel, S. and Patel, A., Chemistry and pharmacology of Piper longum L., Int. J. Pharm. Sci. Rev. Res., 2010, 5(1), 67–76.
- Parmar, V. S. et al., Phytochemistry of the genus Piper. Phyto-chemistry., 1997, 46(4), 597–673.
- Vasavirama, K. and Upender, M., Piperine. A valuable alkaloid from piper species. Int. J. Pharm. Sci., 2014, 6(4), 34–38.
- Govindrajan, V. S. and Stahl, H. W., Crit. Rev. Food Sci. Nutr., 1977, 9(2), 115–225.
- Dubey, R. B. and Sonawat, B. S., Current scenario of adulterants and substitutes of medicinal plants. A review. J. Pharm. Sci. In-nov., 2015, 4, 5; Yoganarasmhan, S. N., Nair, K. V., Shanta, T. R., Sudha, R. and Holla, B. V., Evaluation of South Indian market samples of Pippali. BMEBR, 1997, XVIII(1–2), 43–50; The Wealth of India, CSIR, New Delhi, 1969, vol. III, pp. 115–118.
- Gajurel, P. R., Rethy, P., Kumar, Y. and Singh, B., Piper species (Piperaceae) of North-East India (Arunachal Pradesh), Bishen Singh Mahendra Pal Singh, 2008, pp. 55–103.
- Epstein, W. W., Netz, D. F. and Seidel, J. L., Isolation of piperine from black pepper. J. Chem. Educ., 1993, 70(7), 598–599.
- Raman, N., Phytochemical Techniques, New India Publishing Agency, 2006, p. 19.
- Raman, G. and Gaikar, V. G., Extraction of Piperine from Piper nigrum (Black Pepper) by hydrotropic solubilization. Ind. Eng. Chem. Res., 2002, 41(12), 2966–2976.
- Banerji, J. and Dhara, K. P., Lignan and amides from Piper syl-vaticum. Phytochemistry, 1974, 13(10), 2327–2328; Mahanta, P. K., Ghanim, A. and Gopinath, K. W., Chemical constituents of Piper sylvaticum (Roxb) and piper boehmerifolium (Wall). J. Pharm. Sci., 1974, 63(7), 1160–1161; Banerji, A., Rej, R. N. and Ghosh, P., Isolation of N-isobutyldeca-trans-2-trans-4-dienamide from Piper sylvaticum. Experientia, 1974, 30(3), 223–224.
- Dhar, K. L. and Atal, C. K., Indian J. Chem., 1967, 5, 588–589.
- Drinking Water Contamination from Peri-Urban Bengaluru, India
Abstract Views :340 |
PDF Views:66
Authors
Affiliations
1 School of Life Sciences, Trans-Disciplinary University, Bengaluru 560 064, IN
1 School of Life Sciences, Trans-Disciplinary University, Bengaluru 560 064, IN
Source
Current Science, Vol 113, No 09 (2017), Pagination: 1702-1709Abstract
The presence of diarrhoeagenic bacteria such as Escherichia coli in drinking water indicates faecal and sewage contamination. Testing the microbial quality of drinking water at source (n = 29) and households (n = 43) of 29 peri-urban villages of Bengaluru city, indicated that 80% and 93% of samples respectively were unfit for human consumption as per WHO standards, i.e. nil E. coli in 100 ml sample. This also indicated that water gets contaminated further at the point-of-use when compared to the source. Forty-one per cent of the source drinking water samples had high E. coli counts which in turn means that the residing population face moderate to high risk of diarrhoea. A longitudinal study of the microbial quality of drinking water at source of supply (n = 45) was undertaken five times over an eight-month period in a subset of eight villages. Only around 18% of the total samples were microbially safe with nil E. coli/100 ml. Microbial contamination was found to be lower in January and March (<30 CFU/100 ml E. coli) when compared to December, May and September (>150 CFU/100 ml). Samples from Chikkakuntanahalli and Kodiyalakeranahalli had ≥1000 CFU/100 ml E. coli. Total dissolved solids, calcium, magnesium, alkalinity and hardness in source drinking water of eight selected villages were beyond acceptable levels. The nitrate levels were consistently high and beyond WHO permissible levels. Alarming levels of microbial and chemical contamination of drinking water from the sites press for appropriate remedial measures to reduce health threats, particularly among vulnerable population.Keywords
Microbial Contamination, Peri-Urban Bengaluru, Vrishabhavathi–Byramangala Reservoir, Water Quality.Full Text
References
- WHO, Recognition of safe water and sanitation as a human right, 2010; http://www.who.int/water_sanitation_health/recognition_safe_clean_water/en/ (accessed on 13 June 2016).
- WHO-UNICEF, Meeting the MDG drinking water and sanitation target: The urban and rural challenge of the decade, 2006; http://www.who.int/water_sanitation_health/monitoring/jmpfinal.pdf (accessed on 13 June 2016).
- WHO, Water Sanitation and Health, 2008; http://www.who.int/water_sanitation_health/mdg1/en/ (accessed on 13 June 2016).
- WHO, WHO World Water Day Report, 2014. http://www.who.int/water_sanitation_health/takingcharge.html (accessed on 13 June 2016).
- WHO, Unsafe water, sanitation and hygiene, 2010; http://www.who.int/publications/cra/chapters/volume2/1321-1352.pdf (accessed on 13 June 2016).
- WHO, Diarrhoeal disease, 2013; http://www.who.int/mediacentre/factsheets/fs330/en/ (accessed on 13 June 16).
- CDC, Global water, sanitation and hygiene (WASH); 2013; http://www.cdc.gov/healthywater/global/wash_statistics.html (accessed on 13 June 2016).
- UNESCO, Water for a sustainable world, 2015; http://www.cdc.gov/healthywater/global/wash_statistics.html (accessed on 13 June 2016).
- WHO, Drinking-water, 2015; http://www.who.int/mediacentre/factsheets/fs391/en/ (accessed on 13 June 2016).
- World Bank, India Ground water: a valuable but diminishing resource, 2012; http://www.worldbank.org/en/news/feature/2012/03/06/india-groundwater-critical-diminishing (accessed on 13 June 2016).
- Bartram, J. and Ballance, R., Water Quality Monitoring – A Practical Guide to the Design and Implementation of Freshwater Quality Studies and Monitoring Programmes, UNEP/WHO, 1996.
- WHO, Guidelines for drinking-water quality – Surveillance and control of community: supplies, 1997, vol. 3, 2nd edn, pp. 77–79.
- BIS, Drinking water – Specification IS 10500: 1991: Indian Standard, 2012, Second Revision, pp. 1–6.
- WHO, Guidelines for Drinking-water Quality, Third edition incorporating the first and second addenda Volume 1, Recommendations, 2008, pp. 3–7.
- Department of Mines and Geology, Ground water hydrology and ground water quality in and around Bangalore city, 2011, pp. 60, 80–81.
- Jadhav, J. and Gopinath, D., Bacteriological quality of water and water borne diseases in Bangalore. Australiasian Med. J., 2010, 3(12), 803–807.
- Latha, N. and Ramachandra Mohan, M., Evaluation of bacteriological water quality, Bangalore – in view of public health. Int. J. Chem. Stud., 2014, 2(1), 12–18.
- Shankar, B. S., Balasubramanya, N. and Reddy, M. T., Hydrochemical assessment of the pollutants in ground waters of Vrishabhavathi Valley Basin in Bangalore (India). J. Environ. Sci. Eng., 2008, 50(2), 97–102.
- Jayadev and Puttaih, E. T., Studies on heavy metals contamination in Vrishabhavathi river water and ground water of the surrounding river. Int. J. Sci. Eng. Res., 2013, 4(1), 1–9.
- Sivasakthivel, S. and Nandini, N., Health risk assessment of microbial water quality and bioaerosols emission from Byramangala Reservior, Karnataka, India. IJSR, 2014, 3(7), 510–514.
- Jadhav, J. R. K. S. G. D., A study of socio-cultural factors, water quality and Diarrhoea in Bangalore. Int. J. Public Health, 2009, 1(1), 1–4.
- Khayum, A., Nandini, N., Chandrashekar, J. S. and Durgesh, R., Assessment of drinking water quality of Bangalore west zsone, India – a case study. Environ. We. Int. J. Sci. Tech., 2011, 6, 113–122.
- Madhukar, R. and Srikantaswamy, S., Impact of industrial effluents on the water quality of Vrishabavathi river and Byramangala lake in Bidadi industrial area, Karnataka, India. Int. J. Geol. Earth Env. Sci., 2013, 3(2), 132–141.
- Sreedhara Nayaka, B. M., Jayaprakash and Ramakrishna, S., Bacteriological quality of drinking water around Vrishabhavathi valley of Bangalore, Karnataka. Asian Microbiol. Biotech. Env.. Sci., 2008, 10(4), 773–776.
- Skariyachan, S., Lokesh, P., Rao, R., Kumar, A. U., Vasist, K. S. and Narayanappa, R., Pilot study on water pollution and characterization of multidrug-resistant superbugs from Byramangala tank, Ramanagara district, Karnataka, India. Environ. Monit. Assess., 2012, 185, 5483–5495.
- Balasubramanya, N. and Shankar, B. S., Progressive deterioration of groundwater quality in Vrishabhavathi Valley Basin, Bangalore, India. Int. J. Innov. Res. Adv. Eng., 2014, 1(5) 61–66.
- WHO, Nitrate and Nitrite in Drinking-water: Background document for development of WHO Guidelines for Drinking-water Quality, 2011, pp. 1–31.
- Shrivastavad, K., Chandra, T. P. and Yadav, S., Seasonal variation in bacterial contamination of drinking water in bilaspur city of Chhattisgarh state. Indian J. Sci. Res., 2014, 4(1), 185–190.
- Bain, R., Cronk, R., Wright, J., Yang, H., Slaymaker, T. and Bartram, J., Faecal contamination of drinking-water in low- and middle-income countries: a systematic review and meta-analysis. PLoS Med., 2014, 11(5), e1001644.
- WHO/UNICEF, Progress on drinking water and sanitation update, 2012 and 2014, pp. 8–18.
- Rose, A. et al., Solar disinfection of water for diarrhoeal prevention in southern India. Arch. Dis. Child, 2006, 91(2), 139–141.
- Boisson, S., Stevenson, M., Shapiro, L., Kumar, V., Singh, L. P., Ward, D. and Clasen, T., Effect of household-based drinking water chlorination on diarrhoea among children under five in Orissa, India: a double-blind randomised placebo-controlled trial. PLoS Med., 2013, 10(8), e1001497.
- Sudha, V. B., Ganesan, S., Pazhani, G. P., Ramamurthy, T., Nair, G. B. and Venkatasubramanian, P., Storing drinking-water in copper pots kills contaminating diarrhoeagenic bacteria. J. Health Popul. Nutr., 2012, 30(1), 17–21.
- Bioactive Metabolite Profiling for Identification of Elite Germplasms:A Conservation Strategy for Threatened Medicinal Plants
Abstract Views :273 |
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Authors
Affiliations
1 TransDisciplinary University, Foundation for Revitalisation of Local Health Traditions, 74/2, Jarakabhande Kaval, Attur Post, via Yelahanka, Bengaluru 560 106, IN
2 G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi-Katarmal, Almora 263 643, IN
1 TransDisciplinary University, Foundation for Revitalisation of Local Health Traditions, 74/2, Jarakabhande Kaval, Attur Post, via Yelahanka, Bengaluru 560 106, IN
2 G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi-Katarmal, Almora 263 643, IN
Source
Current Science, Vol 114, No 03 (2018), Pagination: 554-561Abstract
Medicinal plants are used as a source of raw drugs, chemical compounds or bioactive metabolites. Many of the medicinal plant species are facing threat of extinction due to indiscriminate harvesting by humans. Conservation of such species is no longer an altruistic choice but a necessity to ensure sustainable supply of bioactive compounds to the drug industry. This article demonstrates that conservation of threatened species is possible through large-scale cultivation of elite germplasm identified using biochemical markers. Six species, viz. Aconitum balfourii Stapf, Aconitum heterophyllum Wall. ex Royle, Podophyllum hexandrum Royle (syn = Sinopodophyllum hexandrum (Royle) T. S. Ying), Picrorhiza kurroa Royle ex Berth., Berberis aristata DC. and Embelia ribes Burm. f. were selected for the study under the all-India coordinated project on threatened species. The approach proved to be effective for bringing back the species from the verge of extinction.Keywords
Bioactive Metabolites, Conservation Strategy, Medicinal Plants, Elite Germplasm.Full Text
References
- Collin, H. A., Secondary metabolite formulations in plant tissue cultures. Plant Growth Regul., 2001, 34, 119–134.
- Sarup, P., Bala, S. and Kamboj, S., Pharmacology and phytochemistry of oleo-gum resin of Commiphora wightii (Guggulu). Scientifica, 2015, 2015, 138039.
- Nadeem, M., Palni, L. M. S., Kumar, A. and Nandi, S. K., Podophyllotoxin content, above- and below-ground biomass in relation to altitude in Podophyllum hexandrum populations from Kumaun region of the Indian central Himalaya. Planta Med., 2007, 73, 388–391.
- Pandey, H., Nandi, S. K., Kumar, A., Agnihotri, R. K. and Palni, L. M. S., Aconitine alkaloids from tubers of Aconitum heterophyllum and A. balfourii: critically endangered medicinal herbs of Indian Central Himalaya. Natl. Acad. Sci. Lett., 2008, 31, 89–93.
- Pandey, H., Nandi, S. K. and Palni, L. M. S., Podophyllotoxin content in leaves and stem of Podophyllum hexandrum Royle from Indian Himalayan region. J. Med. Plants Res., 2013, 7, 3237–3241.
- Pandey, H., Kumar, A., Palni, L. M. S. and Nandi, S. K., Podophyllotoxin content in rhizome and ischolar_main samples of Podophyllum hexandrum Royle populations from Indian Himalayan region. J. Med. Plants Res., 2015, 9, 320–325.
- Naik, P. K., Alam, M. A., Singh, H., Goyal, V., Parida, S., Kalia, S. and Mohapatra, T., Assessment of genetic diversity through RAPD, ISSR and AFLP markers in Podophyllum hexandrum: a medicinal herb from the north-western Himalayan region. Physiol. Mol. Biol. Plant, 2010, 16, 135–148.
- Tiwari, S. S., Pandey, M. M., Srivastava, S. and Rawat, A. K. S., TLC densitometric quantifiation of picrosides (picroside-I and picrosideII) in Picrorhiza kurrooa and its substitute Picrorhiza scrophulariiflra and their antioxidant studies. Biomed. Chromatogr., 2012, 26, 61–68.
- Kuruvilla, G. R., Neeraja, M., Srikrishna, A., Rao, G. S. R. S., Sudhakar, A. V. S. and Venkatasubramanian, P., A new quinone from Maesa indica (Roxb.) A.DC, (Myrsinaceae). Indian J. Chem., 2010, 49B, 1637–1641.
- Venkatasubramanian, P., Kumar, S. K. and Nair, V. S., Cyperus rotundus, a substitute for Aconitum heterophyllum: studies on the ayurvedic concept of Abhava Pratinidhi Dravya (drug substitution). J. Ayurveda Integr. Med., 2010, 1(1), 33–39.
- Ajikumar, P. K., Tyo, K., Carlsen, S., Mucha, O., Phon, T. H. and Stephanopoulos, G., Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms. Mol. Pharm., 2008, 5(2), 167–190.
- Sacchettini, J. C. and Poulter, C. D., Creating isoprenoid diversity. Science, 1997, 277, 1788–1789.
- Grassmann, J., Terpenoids as plant antioxidants. Vit. Horm., 2005, 72, 505–535.
- Irchhaiya, R. et al., Metabolites in plants and its classification. World J. Pharm. Pharm. Sci., 2015, 4(1), 287–305.
- Lu, J. J., Bao, J. L., Chen, X. P., Huang, M. and Wang, Y. T., Alkaloids isolated from natural herbs as the anticancer agents. Evid. Based Complement. Alter. Med., 2012, 2012, 485042.
- Cordell, G. A., Introduction to Alkaloids. A Biogenetic Approach, Wiley-Interscience, New York, USA, 1981.
- Hesse, M., Alkaloids – Nature’s Curse or Blessing, Wiley-VCH, Weinheim, 2002.
- Buckingham, J., Baggaley, K. H., Roberts, A. D. and Szabo L. F., Dictionary of Alkaloids, CRC Press, Florida, USA, 2010.
- Cheynier, V., Comte, G., Davies, K. M., Lattanzio, V. and Martens, S., Plant phenolics: recent advances on their biosynthesis, genetics, and ecophysiology. Plant Physiol. Biochem., 2013, 72, 1–20.
- Pandey, K. B. and Rizvi, S. I., Plant polyphenols as dietary antioxidants in human health and disease. Oxid. Med. Cell Longev., 2009, 2(5), 270–278.
- Croteau, R., Kutchan, T. M. and Lewis, N. G., Biochemistry and Molecular Biology of Plants, John Wiley and Sons, Oxford, UK, 2000.
- Buckingham, J. and Munasinghe, V. R. N., Dictionary of Flavonoids, CRC Press, Florida, USA, 2015.
- Yao, L. H., Jiang, Y. M., Shi, J., Tomás-Barberán, F. A., Datta, N., Singanusong, R. and Chen, S. S., Flavonoids in food and their health benefits. Plant Foods Hum. Nutr., 2004, 59(3), 113–122.
- Vetter, J., Plant cyanogenic glycosides. Toxicon, 2000, 38(1), 11–36.
- Sultankhodzhaev, M. N. and Nishnov, A. A., Proposed biogenesis of diterpenoid alkaloid. Chem. Nat. Prod., 1995, 31, 283–298.
- Srivastava, N., Sharma, V., Kamal, B. and Jadon, S., Aconitum: need for sustainable exploitation (with special reference to Uttarakhand). Int. J. Green Pharm., 2010, 4(4), 220–228.
- Nagarajan, M., Kuruvilla, G. R., Kumar, K. S. and Venkatasubramanian, P., Pharmacology of Ativisha, Musta and their substitutes. J. Ayurveda Integr. Med., 2015, 6(2), 121–133.
- Canel, C., Moraes, R. M., Dyan, F. E. and Ferreira, D., Molecules of interest: podophyllotoxin. Phytochemistry, 2000, 54, 115–120.
- Schacter, L., Etoposide phosphate: what, why, where and how? Sem. Oncol., 1996, 23, 1–7.
- Van Uden, W., Pras, N., Visser, J. F. and Malingre, T. M., Detection and identification of podophyllotoxin produced by cell cultures derived from Podophyllum hexandrum Royle. Plant Cell Rep., 1989, 8, 165–168.
- Fay, D. A. and Ziegler, W., Botanical source differentiation of Podophyllum resin by high performance liquid chromatography. J. Liq. Chromatogr., 1985, 8, 1501–1506.
- Anon., The Ayurvedic Pharmacopoeia of India, Part I, Vol. II, Government of India, Ministry of Health and Family Welfare, Department of Indian Systems of Medicine & Homoeopathy, 1999.
- Sack, R. B. and Froehlich, J. L., Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infect. Immunol., 1982, 35(2), 471–475.
- Kirtikar, K. R. and Basu, B. D., Indian Medicinal Plants, International Book Publications, Dehradun, 1995.
- Ved, D. K. and Goraya G. S., Demand and Supply of Medicinal Plants, Foundation for Revitalization of Local Health Traditions, Bangalore, 2008.
- Saied, S., Batool, S. and Naz, S., Phytochemical studies of Berberis aristata. J. Basic Appl. Sci., 2007, 3(1), 1–4.
- Wongbutdee, J., Physiological effects of berberine. Thai Pharm. Health Sci. J., 2009, 4, 78–83.
- Affuso, F., Ruvolo, A., Micillo, F., Saccà, L. and Fazio, S., Effects of a nutraceutical combination (berberine, red yeast rice and policosanols) on lipid levels and endothelial function randomized, double-blind, placebo-controlled study. Nutr. Metab. Cardiovasc. Dis., 2010, 20(9), 656–661.
- Mhaskar, M., Joshi, S., Chavan, B., Joglekar, A., Barve, N. and Patwardhan, A., Status of Embelia ribes Burm f. (Vidanga), an important medicinal species of commerce from northern Western Ghats of India. Curr. Sci., 2011, 100(4), 547–525.
- Souravi, K. and Rajasekharan, P. E., A review on the pharmacology of Embelia ribes Burm. F. – a threatened medicinal plant. Int. J. Pharm. Biol. Sci., 2014, 5(2), 443–456.
- Purohit, A. N., Lata, H., Nautiyal, S and Purohit, M. C., Some characteristics of four morphological variants of Podophyllum hexandrum Royle. Plant Genet. Res. Newsl., 1998, 114, 51–52.
- Sharma, T. R., Singh, B. M., Sharma, N. R. and Chauhan, R. S., Identification of high podophyllotoxin producing biotypes of Podophyllum hexandrum Royle from North-Western Himalaya. J. Plant Biochem. Biotechnol., 2000, 9, 49–51.
- Kitchlu, S., Ram, G., Koul, S., Koul, K., Gupta, K. K. and Ahuja, A., Podophyllum lignans array of Podophyllum hexandrum Royle population from semi-desert alpine region of Zanskar valley in Himalayas. Ind. Crops Prod., 2011, 33, 584–587.
- Pandey, H., Nandi, S. K., Kumar, A., Palni, U. T. and Palni, L. M. S., Podophyllotoxin content in Podophyllum hexandrum Royle plants of known age of seed origin and grown at a lower altitude. Acta. Physiol. Plant, 2007, 29, 121–126.
- Bastos, J. K., Burandt, Jr, Nanayakkara, L. and Bryanat Mechesney, J. D., Quantification of aryltetralin lignans in plants parts and among different populations of Podophyllum peltatum by reverse phase high performance liquid chromatography. J. Nat. Prod., 1996, 59, 406–408.
- Moraes, R. M., Momm, H. G., Silva, B., Maddox, V., Easson, G. L., Lata, H. and Ferreira, D., Geographic information system method for assessing chemo-diversity in medicinal plants. Planta Med., 2005, 71, 1157–1164.
- Purohit, H., Nautiyal, B. P. and Nautiyal, M. C., Interpopulation variation in Picrorhiza kurrooa Royle ex Benth – step towards identifying genetic variability and elite strains for crop improvement study. Am. J. Plant Physiol., 2008, 3, 154–164.
- Sharma, N., Pathania, V., Singh, B. and Gupta, R. C., Intraspecific variability of main phytochemical compounds in Picrorhiza kurrooa Royle ex Benth. from north Indian higher altitude Himalayas using reverse-phase high performance liquid chromatography. J. Med. Plants Res., 2012, 6, 3181–3187.
- Sarin, Y. K., Illustrated Manual of Herbal Drugs used in Ayurveda (CSIR/ICMR), NISCOM, New Delhi, 1996.
- Anon., The Ayurvedic Formulary of India, Part I, Government of India, Ministry of Health and Family Welfare, Department of Indian Systems of Medicine and Homoeopathy, New Delhi, 2003.
- Choudhury, R. P., Md. Ibrahim, A. and Bharathi, Padma, V., Quantitative analysis of embelin in Myrsine africana L. (Myrsinaceae) using HPLC and HPTLC. E-J. Food Plants Chem., 2007, 2, 20–24.
- Fowler, M. W., Problems in commercial exploitation of plant tissue cultures. In Primary and Secondary Metabolism of Plant Cell Cultures (eds Neumann, K. H., Barz, W. and Reinhardt, E.), Springer Verlag, Berlin, Germany, 1985, pp. 362–378.
- Hussain, M. S., Fareed, S., Ansari, S., Rahman, M. A., Ahmad, I. Z. and Saeed, M., Current approaches toward production of secondary plant metabolites. J. Pharm. Bioallied Sci., 2012, 4(1), 10–20.
- Caruso, M. et al., Studies on a strain of Kitasatospora sp. paclitaxel producer. Ann. Microbiol., 2000, 50(2), 89–102.
- Golinska, P., Wypij, M., Agarkar, G., Rathod, D., Dahm, H. and Rai, M., Endophytic actinobacteria of medicinal plants: diversity and bioactivity. Antonie Van Leeuwenhoek, 2015, 108(2), 267–289.
- Moraes, R. M., Burandt, C. L., Ganzera, M., Li, X., Khan, I. A. and Canel, C., The American May apple revisited – Podophyllum peltatum – still a potential cash crop? Econ. Bot., 2000, 54, 471–476.
- Moraes, R. M., Bedir, E., Burandt, C., Canel, C. and Khan, I. A., Evaluation of Podophyllum peltatum accessions for podophyllotoxin production. Planta Med., 2002, 68, 341–344.
- Zheljazkov, V. D., Cantrell, C. L. and Astatkie, T., Variation in podophyllotoxin concentration in leaves and rhizomes of American mayapple (Podophyllum peltatum L.). Ind. Crops Prod., 2011, 33, 633–637.